From the Behavioral Pharmacology of Beta-Carbolines to Seizures, Anxiety, and Memory

A number of beta-carbolines are inverse agonists of the GABA-A receptor complex, acting on the benzodiazepine site. They show convulsive properties when administered at high doses, anxiogenic properties at moderate doses, and learning-enhancing effects at low doses. These data suggest a possible phy...

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Bibliographic Details
Main Authors: Patrice Venault, Georges Chapouthier
Format: Article
Language:English
Published: Hindawi Limited 2007-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2007.48