Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: Incorporating EGFR signaling pathway and angiogenesis

<p>Abstract</p> <p>Background</p> <p>The epidermal growth factor receptor (EGFR) signaling pathway and angiogenesis in brain cancer act as an engine for tumor initiation, expansion and response to therapy. Since the existing literature does not have any models that inve...

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Bibliographic Details
Main Authors: Sun Xiaoqiang, Zhang Le, Tan Hua, Bao Jiguang, Strouthos Costas, Zhou Xiaobo
Format: Article
Language:English
Published: BMC 2012-08-01
Series:BMC Bioinformatics
Subjects:
Online Access:http://www.biomedcentral.com/1471-2105/13/218