Suppression of Hepatitis C Virus Genome Replication and Particle Production by a Novel Diacylglycerol Acyltransferases Inhibitor

Suppression of Hepatitis C Virus Genome Replication and Particle Production by a Novel Diacylglycerol Acyltransferases Inhibitor

Diacylglycerol acyltransferases (DGATs) play a critical role in the biosynthesis of endogenous triglycerides (TGs) and formation of lipid droplets (LDs) in the liver. In particular, one member of DGATs, DGAT-1 was reported to be an essential host factor for the efficient production of hepatitis C vi...

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Bibliographic Details
Main Authors: Dahee Kim, Ja-Il Goo, Mi Il Kim, Sung-Jin Lee, Moonju Choi, Thoa Thi Than, Phuong Hong Nguyen, Marc P. Windisch, Kyeong Lee, Yongseok Choi, Choongho Lee
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
hepatitis C virus (HCV)
diacylglycerol acyltransferase (DGAT)
lipid droplet (LD)
DGAT inhibitor
HCV genome replication
HCV particle production
Online Access:http://www.mdpi.com/1420-3049/23/8/2083

Internet

http://www.mdpi.com/1420-3049/23/8/2083

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