IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

Abstract Background Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also increase Th2-type cytokine expression. We hypothesised that IL-1β is causa...

Full description

Bibliographic Details
Main Authors: Irma Mahmutovic Persson, Mandy Menzel, Sangeetha Ramu, Samuel Cerps, Hamid Akbarshahi, Lena Uller
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Respiratory Research
Subjects:
Asthma exacerbation
HDM
IL-1β
IL-33
Mouse model
Neutrophilia
Online Access:http://link.springer.com/article/10.1186/s12931-018-0725-z

Internet

http://link.springer.com/article/10.1186/s12931-018-0725-z

Similar Items