Global DNA methylation levels in white blood cells of patients with chronic heroin use disorder. A prospective study

Background: Increasing scientific evidence shows the significant role of epigenetic mechanisms in drug use disorder, abstinence and relapse. Studies on human subjects are limited compared to those on animals, for various reasons such as poly-substance abuse, high drop-out rate and technical difficul...

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Bibliographic Details
Main Authors: Domniki Fragou, Mu-Rong Chao, Chiung-Wen Hu, Kakia Nikolaou, Leda Kovatsi
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Toxicology Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750021000238