Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition

Aldosterone (Aldo), when overproduced, is a cardiotoxic hormone underlying heart failure and hypertension. Aldo exerts damaging effects via the mineralocorticoid receptor (MR) but also activates the antiapoptotic G protein-coupled estrogen receptor (GPER) in the heart. G protein-coupled receptor (GP...

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Bibliographic Details
Main Authors: Jennifer Maning, Katie A. McCrink, Celina M. Pollard, Victoria L. Desimine, Jennifer Ghandour, Arianna Perez, Natalie Cora, Krysten E. Ferraino, Barbara M. Parker, Ava R. Brill, Beatrix Aukszi, Anastasios Lymperopoulos
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
aldosterone
cardiac myocyte
G protein-coupled receptor kinase
G protein-coupled estrogen receptor
mineralocorticoid receptor
signal transduction
Online Access:https://www.mdpi.com/1422-0067/21/8/2868

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https://www.mdpi.com/1422-0067/21/8/2868

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