Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components

Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components

Abstract Background Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling mechanisms are incompletely understood. To gain more insight into these mechanisms, the ER stressor thapsigargin (Tg) is an in...

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Bibliographic Details
Main Authors: Paula Lindner, Søren Brøgger Christensen, Poul Nissen, Jesper Vuust Møller, Nikolai Engedal
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Cell Communication and Signaling
Subjects:
Thapsigargin
SERCA
Unfolded protein response
DR5
Caspase-8
PERK
Online Access:https://doi.org/10.1186/s12964-019-0499-z

Internet

https://doi.org/10.1186/s12964-019-0499-z

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