Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous Recombination Regulation

Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous Recombination Regulation

Srs2 is a super-family 1 helicase that promotes genome stability by dismantling toxic DNA recombination intermediates. However, the mechanisms by which Srs2 remodels or resolves recombination intermediates remain poorly understood. Here, single-molecule imaging is used to visualize Srs2 in real time...

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Bibliographic Details
Main Authors: Luisina De Tullio, Kyle Kaniecki, Youngho Kwon, J. Brooks Crickard, Patrick Sung, Eric C. Greene
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
homologous recombination
Srs2
Rad52
replication protein A
single molecule
DNA curtain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313785

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http://www.sciencedirect.com/science/article/pii/S2211124717313785

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