Anti-Sporothrix brasiliensis activity of different pyrazinoic acid prodrugs: a repurposing evaluation

Anti-Sporothrix brasiliensis activity of different pyrazinoic acid prodrugs: a repurposing evaluation

From drug repurposing studies, this work aimed to evaluate the activity of different pyrazinoic acid (POA) derivatives against Sporothrix brasiliensis. The POA esters were prepared and characterized as previously reported by classical esterification reactions, with good to excellent yields. Sporothr...

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Bibliographic Details
Main Authors: Stefanie Bressan Waller, Ceres Nakasu, Anna Luiza Silva, Renata Osório de Faria, João Paulo dos Santos Fernandes, Marlete Brum Cleff
Format: Article
Language:English
Published: Universidade de São Paulo 2019-04-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Sporotrichosis
Sporothrix schenckii complex
Itraconazole
Antifungal resistance
Prodrugs
Pyrazinoic acid derivatives
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400630&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400630&lng=en&tlng=en

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