Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models

Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models

Ischemic brain injury causes neuronal death and inflammation. Inflammation activates protein-tyrosine phosphatase 1B (PTP1B). Here, we tested the significance of PTP1B activation in glutamatergic projection neurons on functional recovery in two models of stroke: by photothrombosis, focal ischemic le...

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Bibliographic Details
Main Authors: Shelly A Cruz, Zhaohong Qin, Konrad M Ricke, Alexandre F.R. Stewart, Hsiao-Huei Chen
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
adhesive removal test; anxiety; depression; elevated plus maze; forced swimming test; iba1; interleukin-1β; microglia; open field test; tail suspension test; tumor necrosis factor-α
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=1;spage=129;epage=136;aulast=Cruz

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=1;spage=129;epage=136;aulast=Cruz

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