A Computational Approach to Evaluate the Combined Effect of SARS-CoV-2 RBD Mutations and ACE2 Receptor Genetic Variants on Infectivity: The COVID-19 Host-Pathogen Nexus

A Computational Approach to Evaluate the Combined Effect of SARS-CoV-2 RBD Mutations and ACE2 Receptor Genetic Variants on Infectivity: The COVID-19 Host-Pathogen Nexus

SARS-CoV-2 infectivity is largely determined by the virus Spike protein binding to the ACE2 receptor. Meanwhile, marked infection rate differences were reported between populations and individuals. To understand the disease dynamic, we developed a computational approach to study the implications of...

Full description

Bibliographic Details
Main Authors: Dana Ashoor, Noureddine Ben Khalaf, Maryam Marzouq, Hamdi Jarjanazi, Sadok Chlif, M. Dahmani Fathallah
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
COVID-19
SARS-CoV-2
angiotensin converting enzyme 2 receptor
spike
receptor binding domain
virus-host interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.707194/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.707194/full

Similar Items