Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses

Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses

Abstract Background Chronic lung disease resulting from dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) and NFκB-mediated neutrophilic-inflammation forms the basis of CF-related mortality. Here we aimed to evaluate if HDAC inhibition controls Pseudomonas-aeruginosa-lipopolys...

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Bibliographic Details
Main Authors: Manish Bodas, Steven Mazur, Taehong Min, Neeraj Vij
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Respiratory Research
Subjects:
SAHA (suberoylanilide hydroxamic acid)
Cystic fibrosis
CFTR
HDAC
Lung
Online Access:http://link.springer.com/article/10.1186/s12931-017-0705-8

Internet

http://link.springer.com/article/10.1186/s12931-017-0705-8

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