Predicting response to platinum and non-platinum drugs through bioluminescence resonance energy transfer (BRET) based bio-molecular interactions in platinum resistant epithelial ovarian cancer

Predicting response to platinum and non-platinum drugs through bioluminescence resonance energy transfer (BRET) based bio-molecular interactions in platinum resistant epithelial ovarian cancer

Therapy induced rewiring of signalling networks often lead to acquirement of platinum-resistance, thereby necessitating the use of non-platinum agents as second-line treatment particularly for epithelial ovarian cancer (EOC). A prior subject-specific assessment can guide the choice of optimal non-pl...

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Bibliographic Details
Main Authors: Aniketh Bishnu, Megha Mehrotra, Ajit Dhadve, Shalini Dimri, Abhijit De, Pritha Ray
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Translational Oncology
Subjects:
BRET
Chemoresistance
Second line non-platinum drugs
ERK1/2
AKT
HGSOC
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001856

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http://www.sciencedirect.com/science/article/pii/S1936523321001856

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