Gastrin-Releasing Peptide Receptor Mediates Activation of the Epidermal Growth Factor Receptor in Lung Cancer Cells

Gastrin-Releasing Peptide Receptor Mediates Activation of the Epidermal Growth Factor Receptor in Lung Cancer Cells

Gastrin-releasing peptide receptor (GRPR) and the epidermal growth factor receptor (EGFR) are expressed in several cancers including non-small cell lung carcinoma (NSCLC). Here we demonstrate the activation of EGFR by the GRPR ligand, gastrin-releasing peptide (GRP), in NSCLC cells. GRP induced rap...

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Bibliographic Details
Main Authors: Sufi Mary Thomas, Jennifer Rubin Grandis, Abbey L. Wentzel, William E. Gooding, Vivian Wai Yan Lui, Jill M. Siegfried
Format: Article
Language:English
Published: Elsevier 2005-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
EGFR
GRPR
MAPK
signal transduction
non-small cell
lung carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800740

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http://www.sciencedirect.com/science/article/pii/S1476558605800740

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