The siRNA targeted to <it>mdr1b </it>and <it>mdr1a </it>mRNAs <it>in vivo </it>sensitizes murine lymphosarcoma to chemotherapy

The siRNA targeted to <it>mdr1b </it>and <it>mdr1a </it>mRNAs <it>in vivo </it>sensitizes murine lymphosarcoma to chemotherapy

<p>Abstract</p> <p>Background</p> <p>One of the main obstacles for successful cancer polychemotherapy is multiple drug resistance phenotype (MDR) acquired by tumor cells. Currently, RNA interference represents a perspective strategy to overcome MDR via silencing the gen...

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Bibliographic Details
Main Authors: Vlassov Valentin V, Nikolin Valery P, Kaledin Vasily I, Popova Nelly A, Mironova Nadezda L, Patutina Olga A, Zenkova Marina A
Format: Article
Language:English
Published: BMC 2010-05-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/10/204

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http://www.biomedcentral.com/1471-2407/10/204

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