Targeting the DNA Damage Response for the Treatment of High Risk Neuroblastoma

Despite intensive multimodal therapy, the survival rate for high risk neuroblastoma (HR-NB) remains <50%. Most cases initially respond to treatment but almost half will subsequently relapse with aggressive treatment resistant disease. Novel treatments exploiting the molecular pathology of NB...

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Bibliographic Details
Main Authors: Harriet E. D. Southgate, Lindi Chen, Nicola J. Curtin, Deborah A. Tweddle
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
ATR
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00371/full