Generating a Generation of Proteasome Inhibitors: From Microbial Fermentation to Total Synthesis of Salinosporamide A (Marizomib) and Other Salinosporamides

Generating a Generation of Proteasome Inhibitors: From Microbial Fermentation to Total Synthesis of Salinosporamide A (Marizomib) and Other Salinosporamides

The salinosporamides are potent proteasome inhibitors among which the parent marine-derived natural product salinosporamide A (marizomib; NPI-0052; 1) is currently in clinical trials for the treatment of various cancers. Methods to generate this class of compounds include fermentation and natural pr...

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Bibliographic Details
Main Authors: Barbara C. Potts, Kin S. Lam
Format: Article
Language:English
Published: MDPI AG 2010-03-01
Series:Marine Drugs
Subjects:
salinosporamide A
marizomib
NPI-0052
proteasome inhibitor
total synthesis
semi-synthesis
natural products chemistry
fermentation
mutasynthesis
precursor-directed biosynthesis
structure-activity relationships
analogs
Online Access:http://www.mdpi.com/1660-3397/8/4/835/

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http://www.mdpi.com/1660-3397/8/4/835/

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