Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: An hormetic stimulus

Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: An hormetic stimulus

The presence of amyloid aggregates of human islet amyloid polypeptide (hIAPP), a hallmark of type 2 diabetes, contributes to pancreatic β-cell impairment, where oxidative stress plays a key role. A contribution of NADPH oxidase to reactive oxygen species (ROS) generation after cell exposure to micr...

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Bibliographic Details
Main Authors: Elisabetta Borchi, Valentina Bargelli, Valentina Guidotti, Andrea Berti, Massimo Stefani, Chiara Nediani, Stefania Rigacci
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
hIAPP
RAGE
NADPH oxidase
Type 2 diabetes
Antioxidant enzyme
Hormesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231713000931

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http://www.sciencedirect.com/science/article/pii/S2213231713000931

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