Water-soluble version of SCR7-pyrazine inhibits DNA repair and abrogates tumor cell proliferation

Water-soluble version of SCR7-pyrazine inhibits DNA repair and abrogates tumor cell proliferation

Aim: Mammalian DNA Ligases play pivotal role in processes such as DNA replication, recombination, and repair, which qualifies them as potent therapeutic targets to eradicate cancer cells. Recently, we have identified a small molecule inhibitor, SCR7 and its oxidized form SCR7-pyrazine (2-mercapto-6,...

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Bibliographic Details
Main Authors: Monica Pandey, Vidya Gopalakrishnan, Hassan A Swarup, Sujeet Kumar, Radha Gudapureddy, Anjana Elizabeth Jose, Supriya V Vartak, Robin Sebastian, Mrinal Srivastava, Bibha Choudhary, Mantelingu Kempegowda, Subhas S Karki, Sathees C Raghavan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Journal of Radiation and Cancer Research
Subjects:
Cancer therapeutics
CRISPR
DNA ligase
double-strand break
end-joining
genome editing
homologous recombination
nonhomologous end-joining
Online Access:http://www.journalrcr.org/article.asp?issn=2588-9273;year=2019;volume=10;issue=1;spage=27;epage=43;aulast=Pandey

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http://www.journalrcr.org/article.asp?issn=2588-9273;year=2019;volume=10;issue=1;spage=27;epage=43;aulast=Pandey

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