An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.

Seizures in focal epilepsies are sustained by a highly synchronous neuronal discharge that arises at restricted brain sites and subsequently spreads to large portions of the brain. Despite intense experimental research in this field, the earlier cellular events that initiate and sustain a focal seiz...

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Bibliographic Details
Main Authors: Marta Gómez-Gonzalo, Gabriele Losi, Angela Chiavegato, Micaela Zonta, Mario Cammarota, Marco Brondi, Francesco Vetri, Laura Uva, Tullio Pozzan, Marco de Curtis, Gian Michele Ratto, Giorgio Carmignoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20405049/?tool=EBI