BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector...

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Bibliographic Details
Main Authors: Suzana eSalcedo, María Ines eMarchesini, Clara eDegos, Matthieu eTerwagne, Kristine eVon Bargen, Hubert eLepidi, Claudia Karina eHerrmann, Thais Lourdes eSantos Lacerda, Paul eImbert, Philippe ePierre, Lena eAlexopoulou, Jean-Jacques eLetesson, Diego J. Comerci, Jean-Pierre eGorvel
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Brucella
TLR
NF-κB
DC
TIR domain
Btp1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00028/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00028/full

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