Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitrobenzamido)-2-hydroxypropyl]decahydroisoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitrobenzoyl)pyrrolidin-2-yl]-2-hydroxyethyl}decahydroisoquinoline-3-carboxamide

Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitrobenzamido)-2-hydroxypropyl]decahydroisoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitrobenzoyl)pyrrolidin-2-yl]-2-hydroxyethyl}decahydroisoquinoline-3-carboxamide

The crystal structure and absolute configuration of the two new title nelfinavir analogs, C24H35ClN4O5, (I), and C27H39ClN4O5, (II), have been determined. Each of these molecules exhibits a number of disordered moieties. There are intramolecular N—H...O hydrogen bonds in both (I) and (II). In (I) it...

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Bibliographic Details
Main Authors: Tucker Maxson, Jeffery A. Bertke, Danielle L. Gray, Douglas A. Mitchell
Format: Article
Language:English
Published: International Union of Crystallography 2015-11-01
Series:Acta Crystallographica Section E: Crystallographic Communications
Subjects:
crystal structure
chiral crystal
absolute configuration
nelfinavir
HIV protease inhibitor
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2056989015020046

Internet

http://scripts.iucr.org/cgi-bin/paper?S2056989015020046

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