High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer.

High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer.

STAT3 is over-expressed in endometrial cancer, and diabetes is a risk factor for the development of type 1 endometrial cancer. We therefore investigated whether glucose concentrations influence STAT3 expression in type 1 endometrial cancer, and whether such STAT3 expression might be inhibited by met...

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Bibliographic Details
Main Authors: John J Wallbillich, Srirama Josyula, Uksha Saini, Roman A Zingarelli, Kalpana Deepa Priya Dorayappan, Maria K Riley, Ross A Wanner, David E Cohn, Karuppaiyah Selvendiran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5256996?pdf=render

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http://europepmc.org/articles/PMC5256996?pdf=render

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