Structural Biology of DNA (6-4) Photoproducts Formed by Ultraviolet Radiation and Interactions with Their Binding Proteins

Structural Biology of DNA (6-4) Photoproducts Formed by Ultraviolet Radiation and Interactions with Their Binding Proteins

Exposure to the ultraviolet component of sunlight causes DNA damage, which subsequently leads to mutations, cellular transformation, and cell death. DNA photoproducts with (6-4) pyrimidine-pyrimidone adducts are more mutagenic than cyclobutane pyrimidine dimers. These lesions must be repaired becaus...

Full description

Bibliographic Details
Main Authors: Hideshi Yokoyama, Ryuta Mizutani
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:International Journal of Molecular Sciences
Subjects:
DNA damage
DNA (6-4) photoproduct
ultraviolet light
nucleotide flipping
crystal structure
antigen-binding fragment
antibody
photolyase
nucleotide excision repair
Online Access:http://www.mdpi.com/1422-0067/15/11/20321

Internet

http://www.mdpi.com/1422-0067/15/11/20321

Similar Items