Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate

Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate

Our understanding of how the germline of the parasitic flatworm Schistosoma mansoni develops is limited. Here, the authors use single cell RNAseq and functional genomic analysis of juvenile worms to identify a regulatory program that mediates the fate of germline stem cells between proliferation and...

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Main Authors: Pengyang Li, Dania Nanes Sarfati, Yuan Xue, Xi Yu, Alexander J. Tarashansky, Stephen R. Quake, Bo Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20794-w
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spelling doaj-4176f353afde4a5ab745c9d9253508882021-01-24T12:12:31ZengNature Publishing GroupNature Communications2041-17232021-01-0112111210.1038/s41467-020-20794-wSingle-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fatePengyang Li0Dania Nanes Sarfati1Yuan Xue2Xi Yu3Alexander J. Tarashansky4Stephen R. Quake5Bo Wang6Department of Bioengineering, Stanford UniversityDepartment of Biology, Stanford UniversityDepartment of Bioengineering, Stanford UniversityDepartment of Bioengineering, Stanford UniversityDepartment of Bioengineering, Stanford UniversityDepartment of Bioengineering, Stanford UniversityDepartment of Bioengineering, Stanford UniversityOur understanding of how the germline of the parasitic flatworm Schistosoma mansoni develops is limited. Here, the authors use single cell RNAseq and functional genomic analysis of juvenile worms to identify a regulatory program that mediates the fate of germline stem cells between proliferation and differentiation.https://doi.org/10.1038/s41467-020-20794-w
collection DOAJ
language English
format Article
sources DOAJ
author Pengyang Li
Dania Nanes Sarfati
Yuan Xue
Xi Yu
Alexander J. Tarashansky
Stephen R. Quake
Bo Wang
spellingShingle Pengyang Li
Dania Nanes Sarfati
Yuan Xue
Xi Yu
Alexander J. Tarashansky
Stephen R. Quake
Bo Wang
Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate
Nature Communications
author_facet Pengyang Li
Dania Nanes Sarfati
Yuan Xue
Xi Yu
Alexander J. Tarashansky
Stephen R. Quake
Bo Wang
author_sort Pengyang Li
title Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate
title_short Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate
title_full Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate
title_fullStr Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate
title_full_unstemmed Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate
title_sort single-cell analysis of schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-01-01
description Our understanding of how the germline of the parasitic flatworm Schistosoma mansoni develops is limited. Here, the authors use single cell RNAseq and functional genomic analysis of juvenile worms to identify a regulatory program that mediates the fate of germline stem cells between proliferation and differentiation.
url https://doi.org/10.1038/s41467-020-20794-w
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AT daniananessarfati singlecellanalysisofschistosomamansoniidentifiesaconservedgeneticprogramcontrollinggermlinestemcellfate
AT yuanxue singlecellanalysisofschistosomamansoniidentifiesaconservedgeneticprogramcontrollinggermlinestemcellfate
AT xiyu singlecellanalysisofschistosomamansoniidentifiesaconservedgeneticprogramcontrollinggermlinestemcellfate
AT alexanderjtarashansky singlecellanalysisofschistosomamansoniidentifiesaconservedgeneticprogramcontrollinggermlinestemcellfate
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