Timing is not everything: neuromodulation opens the STDP gate

Spike timing dependent plasticity (STDP) is a temporally specific extension of Hebbian associative plasticity that has tied together the timing of presynaptic inputs relative to the postsynaptic single spike. However, it is difficult to translate this mechanism to in vivo conditions where there is a...

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Bibliographic Details
Main Authors: Verena Pawlak, Jeffery R Wickens, Alfredo Kirkwood, Jason N D Kerr
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-10-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsyn.2010.00146/full