A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

Abstract Background Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas signaling was required for axon degeneration and de...

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Bibliographic Details
Main Authors: Anitha Krishnan, Andrew J. Kocab, David N. Zacks, Ann Marshak-Rothstein, Meredith Gregory-Ksander
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Neuroinflammation
Subjects:
Glaucoma
Neuroprotection
Retinal ganglion cell
Fas ligand
Fas receptor
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12974-019-1576-3

Internet

http://link.springer.com/article/10.1186/s12974-019-1576-3

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