High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration[S]

High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration[S]

The fat-1 gene cloned from C. elegans encodes an n-3 fatty acid desaturase that converts n-6 to n-3 PUFA. Mice carrying the fat-1 transgene and wild-type controls were fed an n-3-deficient/n-6-enriched diet [fat-1- safflower oil (SFO) and wt-SFO, respectively]. Fatty acid profiles of rod outer segme...

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Bibliographic Details
Main Authors: Masaki Tanito, Richard S. Brush, Michael H. Elliott, Lea D. Wicker, Kimberly R. Henry, Robert E. Anderson
Format: Article
Language:English
Published: Elsevier 2009-05-01
Series:Journal of Lipid Research
Subjects:
retinal light damage
fat-1
n-3 fatty acid desaturase
4-hydoroxynonenal (4-HNE)
4-hydroxyhexenal (4-HHE)
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520308336

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http://www.sciencedirect.com/science/article/pii/S0022227520308336

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