Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity

Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity

Until now, the dopamine (DA) precursor, L-3,4-dihydroxyphenylalanine (L-DOPA), remains the gold standard effective drug therapy for Parkinson’s disease (PD) patients. Nevertheless, long-term chronic L-DOPA administration leads to the drug efficacy loss and severe adverse effects, such as L-DOPA-indu...

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Bibliographic Details
Main Authors: Di-Sheng Lu, Ce Chen, Ya-Xin Zheng, Dai-Di Li, Guo-Qing Wang, Jie Liu, Jingshan Shi, Feng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Parkinson’s disease
L-DOPA
dyskinesia
Icariin
combination treatment
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00155/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00155/full

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