Effects of antibiotic antitumor drugs on nucleotide levels in cultured tumor cells: an exploratory method to distinguish the mechanisms of antitumor drug action based on targeted metabolomics

Effects of antibiotic antitumor drugs on nucleotide levels in cultured tumor cells: an exploratory method to distinguish the mechanisms of antitumor drug action based on targeted metabolomics

Nucleotide pools in mammalian cells change due to the influence of antitumor drugs, which may help in evaluating the drug effect and understanding the mechanism of drug action. In this study, an ion-pair RP-HPLC method was used for a simple, sensitive and simultaneous determination of the levels of...

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Bibliographic Details
Main Authors: Fang Wang, Xi Liu, Cuichai Liu, Zheng Liu, Lixin Sun
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Nucleotides
Targeted metabolomics analysis
Tumor cells
Potential biomarkers
Mechanisms of antitumor drug action
Antibiotic anticancer drugs
Principal component analysis
Ion-pair HPLC
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383515000544

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http://www.sciencedirect.com/science/article/pii/S2211383515000544

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