Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5

Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5

Background: Aortic dissecting aneurysm (ADA) represents an aortic remodeling disease with a high mortality rate. Fat mass and obesity-associated protein (FTO) exerts RNA demethylation function to regulate gene expression related to stem cell differentiation, DNA damage repair, and tumorigenesis, but...

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Bibliographic Details
Main Authors: Dong Ma, Xiao Liu, Jin-jin Zhang, Jun-jian Zhao, Yan-jie Xiong, Quan Chang, Hong-yan Wang, Peng Su, Jia Meng, Yong-bo Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
aortic dissecting aneurysm
vascular smooth muscle cells
FTO
Klf5
GSK3β
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.592550/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2020.592550/full

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