Signaling through polymerization and degradation: Analysis and simulations of T cell activation mediated by Bcl10.

The adaptive immune system serves as a potent and highly specific defense mechanism against pathogen infection. One component of this system, the effector T cell, facilitates pathogen clearance upon detection of specific antigens by the T cell receptor (TCR). A critical process in effector T cell ac...

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Bibliographic Details
Main Authors: Leonard Campanello, Maria K Traver, Hari Shroff, Brian C Schaefer, Wolfgang Losert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-05-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007986