Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

The conserved Hedgehog (HH) signals control animal development, adult stem cell maintenance and oncogenesis. In Drosophila, the HH co-receptor Patched (PTC) controls both HH gradient formation and signalling. PTC is post-translationally downregulated by HH, which promotes its endocytosis and destabi...

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Bibliographic Details
Main Authors: Amira Brigui, Line Hofmann, Camilla Argüelles, Matthieu Sanial, Robert A. Holmgren, Anne Plessis
Format: Article
Language:English
Published: The Royal Society 2015-01-01
Series:Open Biology
Subjects:
drosophila
signal transduction
intracellular protein trafficking
hedgehog
patched
c2-ww-hect ubiquitin ligase
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150112

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150112

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