Epigenome-Wide Comparative Study Reveals Key Differences Between Mixed Connective Tissue Disease and Related Systemic Autoimmune Diseases

Epigenome-Wide Comparative Study Reveals Key Differences Between Mixed Connective Tissue Disease and Related Systemic Autoimmune Diseases

Mixed Connective Tissue Disease (MCTD) is a rare complex systemic autoimmune disease (SAD) characterized by the presence of increased levels of anti-U1 ribonucleoprotein autoantibodies and signs and symptoms that resemble other SADs such as systemic sclerosis (SSc), rheumatoid arthritis (RA), and sy...

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Bibliographic Details
Main Authors: Elena Carnero-Montoro, Guillermo Barturen, Elena Povedano, Martin Kerick, Manuel Martinez-Bueno, PRECISESADS Clinical Consortium, Esteban Ballestar, Javier Martin, María Teruel, Marta E. Alarcón-Riquelme
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
mixed connective tissue disease
systemic autoimmunity
genome-wide DNA methylation
epigenetics
interferon
meQTL
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01880/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01880/full

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