A Distinct Pool of Nav1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes

A Distinct Pool of Nav1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes

Background: In cardiac ventricular muscle cells, the presence of voltage-gated sodium channels Nav1.5 at the lateral membrane depends in part on the interaction between the dystrophin–syntrophin complex and the Nav1.5 C-terminal PDZ-domain-binding sequence Ser-Ile-Val (SIV motif). α1-Syntrophin, a P...

Full description

Bibliographic Details
Main Authors: Jean-Sébastien Rougier, Maria C. Essers, Ludovic Gillet, Sabrina Guichard, Stephan Sonntag, Doron Shmerling, Hugues Abriel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Physiology
Subjects:
voltage-gated sodium channel
lateral membrane of cardiomyocytes
α1-syntrophin
dystrophin
electrophysiology
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00834/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00834/full

Similar Items