The Composite of 3, 4-Dihydroxyl-Phenyl Lactic Acid and Notoginsenoside R1 Attenuates Myocardial Ischemia and Reperfusion Injury Through Regulating Mitochondrial Respiratory Chain

The Composite of 3, 4-Dihydroxyl-Phenyl Lactic Acid and Notoginsenoside R1 Attenuates Myocardial Ischemia and Reperfusion Injury Through Regulating Mitochondrial Respiratory Chain

Aim3,4-Dihydroxyl-phenyl lactic acid (DLA) and notoginsenoside R1 (R1) are known to protect ischemia and reperfusion (I/R) injury by targeting Sirtuin1/NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10/the Mitochondrial Complex I (Sirt-1/NDUFA10/Complex I) and Rho-associated kinase/adenosine tri...

Full description

Bibliographic Details
Main Authors: Li Yan, Chun-Shui Pan, Yu-Ying Liu, Yuan-Chen Cui, Bai-He Hu, Xin Chang, Xiao-Hong Wei, Ping Huang, Jian Liu, Jing-Yu Fan, Quan Li, Kai Sun, Lu-Lu Yan, Ke He, Jing-Yan Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Physiology
Subjects:
3
4-dihydroxyl-phenyl lactic acid
notoginsenoside R1
myocardium ischemia reperfusion injury
Complex I
Complex V
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.538962/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.538962/full

Similar Items