JMJD1C Ensures Mouse Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming through Controlling MicroRNA Expression

JMJD1C Ensures Mouse Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming through Controlling MicroRNA Expression

The roles of histone demethylases (HDMs) for the establishment and maintenance of pluripotency are incompletely characterized. Here, we show that JmjC-domain-containing protein 1c (JMJD1C), an H3K9 demethylase, is required for mouse embryonic stem cell (ESC) self-renewal. Depletion of Jmjd1c leads t...

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Bibliographic Details
Main Authors: Feng Xiao, Bing Liao, Jing Hu, Shuang Li, Haixin Zhao, Ming Sun, Junjie Gu, Ying Jin
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Stem Cell Reports
Subjects:
JMJD1C
H3K9 demethylase
KLF4
embryonic stem cells
self-renewal
reprogramming
microRNAs
ERK/MAPK signaling
EMT
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303235

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http://www.sciencedirect.com/science/article/pii/S2213671117303235

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