A computational study of astrocytic glutamate influence on post-synaptic neuronal excitability.

The ability of astrocytes to rapidly clear synaptic glutamate and purposefully release the excitatory transmitter is critical in the functioning of synapses and neuronal circuits. Dysfunctions of these homeostatic functions have been implicated in the pathology of brain disorders such as mesial temp...

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Bibliographic Details
Main Authors: Bronac Flanagan, Liam McDaid, John Wade, KongFatt Wong-Lin, Jim Harkin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5919689?pdf=render