Metabolite Profiling and Characterization of LW6, a Novel HIF-1α Inhibitor, as an Antitumor Drug Candidate in Mice

Metabolite Profiling and Characterization of LW6, a Novel HIF-1α Inhibitor, as an Antitumor Drug Candidate in Mice

A novel HIF (hypoxia-inducible factor)-1α inhibitor, the (aryloxyacetylamino)benzoic acid derivative LW6, is an anticancer agent that inhibits the accumulation of HIF-1α. The aim of this study was to characterize and determine the structures of the metabolites of LW6 in ICR mice. Metabolite identifi...

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Bibliographic Details
Main Authors: Kiho Lee, Ji-Yoon Lee, Kyeong Lee, Cho-Rock Jung, Min Ju Kim, Jung Ah Kim, Dong Gu Yoo, Eun Jin Shin, Soo Jin Oh
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
LW6
hypoxia-inducible factor-1α
metabolite identification
hybrid triple quadrupole-linear ion trap mass spectrometer
predictive multiple reaction monitoring-information dependent acquisition-enhanced product ion
Online Access:https://www.mdpi.com/1420-3049/26/7/1951

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https://www.mdpi.com/1420-3049/26/7/1951

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