Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity

Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity

Summary: Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages play a major role in inflammation, we studied the contribution of Mfn2 to the activity of these cells. Pro-inflammatory stimuli su...

Full description

Bibliographic Details
Main Authors: Juan Tur, Selma Pereira-Lopes, Tania Vico, Eros A. Marín, Juan P. Muñoz, Maribel Hernández-Alvarez, Pere-Joan Cardona, Antonio Zorzano, Jorge Lloberas, Antonio Celada
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
macrophages
reactive oxygen species (ROS)
mitochondria
mitofusin
lipopolysaccharide (LPS)
phagocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720310640

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720310640

Similar Items