Metabolomic Analysis by Nuclear Magnetic Resonance Spectroscopy as a New Approach to Understanding Inflammation and Monitoring of Pharmacological Therapy in Children and Young Adults With Cystic Fibrosis

Metabolomic Analysis by Nuclear Magnetic Resonance Spectroscopy as a New Approach to Understanding Inflammation and Monitoring of Pharmacological Therapy in Children and Young Adults With Cystic Fibrosis

15-F2t-Isoprostane, a reliable biomarker of oxidative stress, has been found elevated in exhaled breath condensate (EBC), a non-invasive technique for sampling of airway secretions, in patients with cystic fibrosis (CF). Azithromycin has antioxidant properties in experimental models of CF, but its e...

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Bibliographic Details
Main Authors: Paolo Montuschi, Vincenzina Lucidi, Debora Paris, Enza Montemitro, Rugia Shohreh, Nadia Mores, Dominique Melck, Giuseppe Santini, Fabio Majo, Andrea Motta
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
NMR spectroscopy
metabolomics
isoprostanes
oxidative stress
cystic fibrosis
pharmacotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00595/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00595/full

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