Plasmodium falciparum proteinases: cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase

Plasmodium falciparum proteinases: cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase

Numerous proteinase activities have been shown to be essential for the survival of Plasmodium falciparum. One approach to antimalarial chemotherapy, would be to block specifically one or several of these activities, by using compounds structurally analogous to the substrates of these proteinases. Su...

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Bibliographic Details
Main Authors: I. Florent, S. Le Bonniec, B. Carcy, P. Grellier, O. Mercereau-Puijalon, S. Bonnefoy, D. Dhermy, M. Monsigny, R. Mayer, J. Schrével
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 1994-01-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Plasmodium falciparum
proteinases
spectrin
erythrocyte invasion
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761994000600012

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761994000600012

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