Oleanolic acid inhibits RANKL-induced osteoclastogenesis via ER alpha/miR-503/RANK signaling pathway in RAW264.7 cells

Oleanolic acid inhibits RANKL-induced osteoclastogenesis via ER alpha/miR-503/RANK signaling pathway in RAW264.7 cells

Oleanolic acid (OA) has recently become a research hotspot in the treatment of many human diseases, especially osteoporosis and arthritis. However, the mechanisms are not elucidated completely. We aimed to elucidate the target and the mechanism via which OA inhibited osteoclast differentiation. We u...

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Bibliographic Details
Main Authors: Bao-ping Xie, Li-ying Shi, Jin-ping Li, Ying Zeng, Wei Liu, Si-yuan Tang, Lu-juan Jia, Jie Zhang, Guo-xing Gan
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Oleanolic acid
Osteoclasts
Estrogen receptor alpha (ERα)
Methylpiperidino pyrazole
MicroRNA-503
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219310170

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http://www.sciencedirect.com/science/article/pii/S0753332219310170

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