Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division.

In colon cancer, a highly aggressive disease, progression through the malignant sequence is accompanied by increasingly numerous chromosomal rearrangements. To colonize target organs, invasive cells cross several tissues of various elastic moduli. Whether soft tissue increases malignancy or in contr...

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Bibliographic Details
Main Authors: Morgane Rabineau, Leyla Kocgozlu, Denis Dujardin, Bernard Senger, Youssef Haikel, Jean-Claude Voegel, Jean-Noel Freund, Pierre Schaaf, Philippe Lavalle, Dominique Vautier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3805547?pdf=render