MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.

The "super-relaxed state" (SRX) of myosin represents a 'reserve' of motors in the heart. Myosin heads in the SRX are bound to the thick filament and have a very low ATPase rate. Changes in the SRX are likely to modulate cardiac contractility. We previously demonstrated that the S...

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Bibliographic Details
Main Authors: James W McNamara, Amy Li, Sean Lal, J Martijn Bos, Samantha P Harris, Jolanda van der Velden, Michael J Ackerman, Roger Cooke, Cristobal G Dos Remedios
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5489194?pdf=render

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http://europepmc.org/articles/PMC5489194?pdf=render

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