Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

Abstract Aim We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation. The enzyme nSMase2 is involved in the production of exosome...

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Bibliographic Details
Main Authors: Chunni Zhu, Tina Bilousova, Samantha Focht, Michael Jun, Chris Jean Elias, Mikhail Melnik, Sujyoti Chandra, Jesus Campagna, Whitaker Cohn, Asa Hatami, Patricia Spilman, Karen Hoppens Gylys, Varghese John
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Molecular Brain
Subjects:
Parkinson’s disease
Alpha-synuclein
Extracellular vesicles
Exosomes
Neutral sphingomyelinase-2
Online Access:https://doi.org/10.1186/s13041-021-00776-9

Internet

https://doi.org/10.1186/s13041-021-00776-9

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