Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo

Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo

At the site of injury activated platelets release various mediators, one of which is sphingosine 1-phosphate (S1P). It was the aim of this study to explore whether activated human platelets had a pronociceptive effect in an in vivo mouse model and whether this effect was based on the release of S1P...

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Bibliographic Details
Main Authors: Daniela eWeth, Camilla eBenetti, Caroline eRauch, Gerhard eGstraunthaler, Gerd eGeisslinger, Roger eSabbadini, Richard L Proia, Michaela eKress
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Neuroscience
Subjects:
Platelet
post-operative pain
sphingosine 1-phosphate
heat nociception
S1P Receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00140/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00140/full

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