Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

Abstract Background The impairment of histone acetylation is causally linked to the cognitive decline in Alzheimer’s disease (AD). In addition to histone acetyltransferases (HATs) and histone deacetylases (HDACs), inhibitor of acetyltransferases (INHAT) can also regulate histone acetylation. As a ke...

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Bibliographic Details
Main Authors: Gao-Shang Chai, Qiong Feng, Zhi-Hao Wang, Yu Hu, Dong-Sheng Sun, Xiao-Guang Li, Dan Ke, Hong-Lian Li, Gong-Ping Liu, Jian-Zhi Wang
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
ANP32A
Histone acetylation
Synapse
Memory
Online Access:http://link.springer.com/article/10.1186/s13024-017-0178-8

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http://link.springer.com/article/10.1186/s13024-017-0178-8

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