Overexpression of GATA4 enhances the antiapoptotic effect of exosomes secreted from cardiac colony-forming unit fibroblasts via miRNA221-mediated targeting of the PTEN/PI3K/AKT signaling pathway

Overexpression of GATA4 enhances the antiapoptotic effect of exosomes secreted from cardiac colony-forming unit fibroblasts via miRNA221-mediated targeting of the PTEN/PI3K/AKT signaling pathway

Abstract Background GATA4 is an early cardiac-specific transcription factor, and endogenous GATA4-positive cells play a critical role in cardioprotection after myocardial injury. As functional paracrine units of therapeutic cells, exosomes can partially reproduce the reparative properties of their p...

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Bibliographic Details
Main Authors: Chunshu Hao, Zhengri Lu, Yuanyuan Zhao, Zhong Chen, Chengxing Shen, Genshan Ma, Lijuan Chen
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Stem Cell Research & Therapy
Subjects:
GATA4
Exosome
MicroRNA221
PTEN
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13287-020-01759-8

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http://link.springer.com/article/10.1186/s13287-020-01759-8

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