An ADAMTS3 missense variant is associated with Norwich Terrier upper airway syndrome.

An ADAMTS3 missense variant is associated with Norwich Terrier upper airway syndrome.

In flat-faced dog breeds, air resistance caused by skull conformation is believed to be a major determinant of Brachycephalic Obstructive Airway Syndrome (BOAS). The clinical presentation of BOAS is heterogeneous, suggesting determinants independent of skull conformation contribute to airway disease...

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Bibliographic Details
Main Authors: Thomas W Marchant, Elisabeth Dietschi, Ulrich Rytz, Peter Schawalder, Vidhya Jagannathan, Sheida Hadji Rasouliha, Corinne Gurtner, Andreas S Waldvogel, Ronan S Harrington, Michaela Drögemüller, Jeffrey Kidd, Elaine A Ostrander, Amanda Warr, Mick Watson, David Argyle, Gert Ter Haar, Dylan N Clements, Tosso Leeb, Jeffrey J Schoenebeck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008102

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https://doi.org/10.1371/journal.pgen.1008102

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